apalutamide will lessen the extent or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication which are CYP3A4 substrates may end up in lessen publicity to these medicines.diazepam will enhance the degree or outcome of a